Center for the Study of Cancer Treatment Toxicities, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Rua Cel Nunes de Melo, 1127, Rodolfo Teófilo, 60430-270, Fortaleza, Ceará, Brazil. Center for the Study of Cancer Treatment Toxicities, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Rua Cel Nunes de Melo, 1127, Rodolfo Teófilo, 60430-270, Fortaleza, Ceará, Brazil. cwswanderley@gmail.com. Department of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil. Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil. Center for the Study of Cancer Treatment Toxicities, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Rua Cel Nunes de Melo, 1127, Rodolfo Teófilo, 60430-270, Fortaleza, Ceará, Brazil. robertocesarpljr@gmail.com.